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Bioavailability of Chromium
CHROMEMATE® AFFIRMED GRAS (GENERALLY RECOGNIZED AS SAFE)
BENICIA, Calif., June 29, 2005 -- ChromeMate®, InterHealth Nutraceuticals' patented form of biologically active, niacin-bound chromium, has successfully been affirmed GRAS (Generally Recognized as Safe) for use in functional beverages by the Burdock Group, the nation's leading toxicology specialists in evaluating the safety of food and beverage ingredients. The process involved an intensive review of all safety and toxicology data by a panel of scientific experts.
Generically known as chromium nicotinate or chromium polynicotinate, ChromeMate is a unique, patented form of oxygen-coordinated, niacin-bound chromium that plays an important role in:
- proper insulin function
- maintenance of healthy blood sugar
- maintenance of normal cholesterol levels
- energy production
- promotion of healthy body weight
Protected by three U.S. Patents, four international patents and other worldwide patents pending, ChromeMate is the only form of niacin-bound chromium with proven biological activity.
Studies have shown that ChromeMate is 18-times more bioactive than other forms of niacin-bound chromium and is absorbed and retained 600 percent greater than chromium chloride and 300 percent greater than chromium picolinate*. Additional clinical studies have shown that ChromeMate
- promotes normal cholesterol levels
- reduces body weight
- increases lean body mass
- promotes proper insulin function in the body
One study showed that ChromeMate plus exercise in obese women resulted in significant weight loss, while chromium picolinate did not.
Another study in obese human subjects showed that ChromeMate reduced body fat, while sparing lean muscle mass. All these human clinical studies demonstrated no adverse effects of ChromeMate.
"Two elements were key in the decision to certify ChromeMate for GRAS status," stated Dr. George Burdock, president of the Burdock Group. "First was the historical foundation; trivalent chromium is essential for carbohydrate and lipid metabolism in animals and humans, and has a history of safe use. Further support came from extensive toxicology studies on salts of trivalent chromium, including ChromeMate, that provided safety confirmation according to modern scientific standards. This information, along with other data reviewed, provided the substantiation needed to confidently make the GRAS determination."
The panel of experts who made the GRAS determination included Joseph Borzelleca, Ph.D. (Professor Emeritus, Medical College of Virginia), who has more than 40 years experience in determining the safety of food and beverage ingredients; Robert Cousins, Ph.D. (Boston Family Professor of Human Nutrition and Biochemistry, University of Florida); and George Burdock, Ph.D. (president, Burdock Group). Dr. Burdock is also president of the Food Safety Specialty Section of the Society of Toxicology, the largest toxicological society in the world.
*Note: Statements made in this release have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Research data is available upon request.
Found to be More Bioavailable than Other Chromium Supplements Tested
Researchers at the University of California, Davis, have shown that, in animal models used to evaluate bioavailability in humans, chromium nicotinate ( ChromeMate® ) is absorbed and retained significantly better than either chromium chloride or chromium picolinate. One hour after administration, animals fed ChromeMate® absorbed and retained an average 311% more chromium than chromium picolinate and 672% more than chromium chloride in six tissues tested, including liver, pancreas, kidney, blood, testes and muscle. Absorption and retention decreased in all groups at each successive time point measured (3, 6 and 12 hours), but continued to be greatest in animals fed ChromeMate®
Absorption Influenced by Food Intake
Researchers at the University of California, Berkeley, found that absorption of (-)hydroxycitric acid ( Super CitriMax® ) peaked 2 hours after administration, and that the compound remained in the blood for more than 9 hours after ingestion. Eating a meal shortly after taking Super CitriMax® reduced its absorption by about 60%.
South Asian fruit Garcinia cambogia, Calcium/Potassium (-) hydroxycitric acid (HCA) extract As: CitriMax (Patented.), and Super CitriMax (Patented.)
Shown to be Bioavailable in Humans
Researchers at the University of California, Berkeley, have shown that oral (-)hydroxycitric acid (HCA) as Super CitriMax® is absorbed and retained by obese subjects. Using a new rapid and accurate gas chromatography/mass spectrometric method for measuring blood levels of HCA, the scientists found that blood levels of Super CitriMax® increased for at least 2 hours and remained in the blood for more than 4 hours after ingestion. Absorption rates varied among subjects.
South Asian fruit Garcinia cambogia, Calcium/Potassium (-) hydroxycitric acid (HCA) extract As: CitriMax (Patented.), and Super CitriMax (Patented.)
Niacin-Bound CHROMIUM: Chromium (as chromium polynicotinate acid complex) As: ChromeMate® (Patented.)
In a 1994 University of California, Davis study, researchers found that a key ingredient in Diab-X® was "is absorbed and retained significantly better than chromium chloride or chromium picolinate."