Other Hugely Significant Benefits from Diab-X®

ChromeMate® Found More Effective Than Four Other Chromium Compounds Tested

Increased blood pressure and free radicals often occur when insulin becomes less efficient at maintaining normal blood sugar levels. Chromium, an essential trace mineral, enhances the action of insulin and has previously been shown to protect against the adverse effects of a high-sugar diet on blood pressure in animals.

This study compared the effects of different chromium compounds on sugar-induced high blood pressure and free radical production.

Animals that spontaneously develop hypertension were fed diets supplemented with one of five chromium compounds: ChromeMate® niacin-bound chromium, Cr-picolinate, Cr-acetate, Cr-chloride and a chromium nicotinic acid/amino acid complex (NA-AA), then given sugar water (5% and 10% sucrose) to elevate blood pressure.

All of the chromium compounds except NA-AA effectively prevented the sugar-induced rise in systolic pressure compared to non-supplemented control animals.

ChromeMate®, Cr-acetate and Cr-picolinate also lowered levels of the biomarker for long-term blood sugar control, HbA1C. Only ChromeMate® and acetate significantly reduced free radical damage to fats in both the liver and kidneys as measured by TBARS, while picolinate lowered damage in the kidneys.

These results demonstrate that chromium from various compound forms can act as an antioxidant and offset the effects of sugar-induced blood pressure in this animal model, though only ChromeMate® showed significant beneficial effects on all of the parameters measured.

ChromeMate® Improves Metabolic Disorders in Double-Blind Pilot Study

Metabolic problems such as obesity, unhealthy lipid profiles and glucose intolerance become more common with advancing age.

Suboptimal chromium intake, a common prevalence in the U.S. and western cultures, can also contribute to these metabolic disorders.

ChromeMate®, a unique oxygen-coordinated niacin-bound form of chromium, has previously been shown to promote healthy lipid profiles and glucose metabolism in animals and humans.

In a double-blind pilot study, 2 groups of volunteers received 300 mcg of ChromeMate® or placebo daily for 3 months.

Mean fasting glucose levels were lowered significantly in the ChromeMate® supplemented group, while glucose levels remained unchanged in the placebo group.

Those taking ChromeMate® also experienced a modest drop in mean triglycerides and glycosylated hemoglobin (Hb1Ac), the biomarker for long-term glucose control.

In contrast, mean Hb1Ac increased in the placebo group. The ChromeMate® supplement was well-tolerated with no adverse events reported.

The safety of ChromeMate® has been extensively evaluated in standard acute, chronic and mutagenic toxicology studies (reviewed elsewhere).

In a 3-month sub-chronic study, no significant changes were observed in organ weights, hematology, clinical chemistry or histopathology.

These findings support the use of ChromeMate® to safely improve metabolic disorders in those with inadequate chromium levels.

ChromeMate® Shown to Help in Age-Related Metabolism

ChromeMate® is a bioavailable form of chromium, a trace mineral needed for the metabolism of fats, carbohydrates and proteins.

Advancing age increases the risk for high blood pressure, obesity, unhealthy lipid profiles, insulin resistance and glucose intolerance (inefficient use of insulin or blood sugar by the body).

Experimental and human studies have been conducted to evaluate the safety and potential usefulness of ChromeMate®, a unique oxygen-coordinated niacin-bound chromium ingredient, in age-related metabolic disorders.

ChromeMate® has been shown to significantly lower sugar-induced hypertension in lab animals.

Year-long supplementation of ChromeMate®, grape seed extract and zinc methionine in animals safely reduced systolic blood pressure, free radical damage and improved levels of glycosylated hemoglobin, a measure of blood sugar control.

In aging diabetic animals, increasing doses of ChromeMate® significantly decreased free radical damage in organs, DNA fragmentation (genetic damage) and blood pressure.

ChromeMate® demonstrated low toxicity when acute (extreme) doses were administered in standard safety tests.

Finally, overweight African-American women supplemented with ChromeMate® experienced a significant loss of fat and sparing of lean body mass in a clinical cross-over trial without adverse findings.

These results suggest that ChromeMate® may favorably modify age-associated risk factors and support its use as a safe dietary supplement.

ChromeMate® Shown to Ameliorate Symptoms of Syndrome X

Metabolic Syndrome (Syndrome X) is a cluster of risk factors, including obesity, greater abdominal fat, insulin resistance, hypertension and blood lipid abnormalities.

Metabolic Syndrome has been linked to the development of type 2 diabetes, cardiovascular disease and aging. Maintaining optimal insulin and blood sugar metabolism has been reported to slow the aging process in laboratory animals.

This study examined the effects of three supplements in animals that develop features of Metabolic Syndrome and diabetes with age.

Three groups of older rats were supplemented with ChromeMate®, Super CitriMax®, or a maitake mushroom fraction for 6 weeks, while a fourth group served as controls.

During the final 3 weeks, a group was given a combination of all three supplements and compared to untreated animals. All three supplemented groups showed significantly lower systolic blood pressure, as well as less free radical damage in liver and kidney tissues over the initial 6 weeks.

During that period, body weight significantly declined in control animalsa decline that is characteristic of these animals during the later stages of failing health.

In contrast, both the ChromeMate® and maitake supplements largely prevented this anticipated loss.

The Super CitriMax® group also lost weight, though fewer experienced a greater than average drop compared to controls.

Most importantly, treatment with the combined supplements resulted in a lower systolic blood pressure and better body weight maintenance overall. Results from other experimental studies in younger insulin-resistant animalsas well as clinical trialsshow that ChromeMate®, Super CitriMax® or maitake can favorably alter many risk factors associated with Metabolic Syndrome.

The findings from this study suggest that dietary supplements of ChromeMate®, Super CitriMax® and maitake may also benefit people with diabetes, as well as the elderly.

ChromeMate® and OptiZinc® Found to Reduce Signs of Aging

Researchers at Georgetown University Medical Center and Creighton University School of Pharmacy have shown that a combination of ChromeMate®, OptiZinc® and grape seed extract can influence metabolic changes associated with aging.

Experimental animals that received the supplements for a one-year period had lower blood pressure, less free radical formation, and lower levels of glucose-linked proteins (associated with poor glucose regulation) than control animals.

No signs of toxicity were associated with long-term consumption of these supplements.